Archive for the ‘insomnia’ tag
Rozerem
Demonstrated efficacy and safety in older patients, night after night
Rozerem did not impair balance or memory in older adults.
Ramelteon, marketed as Rozerem by Takeda Pharmaceuticals North America, is the first in a new class of sleep agents that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), versus binding to GABA A receptors, such as with drugs like zolpidem, eszopiclone, and zaleplon. Ramelteon is approved by the U.S. Food and Drug Administration (FDA) for long-term use.
Ramelteon does not show any appreciable binding to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects.
Ramelteon is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse, and the withdrawal and rebound insomnia that is typical with other GABA modulators is not present in ramelteon. It is currently the only non-scheduled prescription drug for the treatment of insomnia available in the United States. Some clinicians also use ramelteon for the treatment of Delayed sleep phase disorder.
From Wikipedia (text available under Creative Commons Attribution/Share-Alike License)
Brand name: Rozerem
Generic name/category: Ramelteon, Sedatives, Indanes
Company: Takeda Pharmaceuticals North America
Country/Market: USA, North America
Indication(s)/use: insomnia, difficulty with sleep onset
Target: Healthcare Professionals (HCP)
Medium: Print ad
Size/duration double-page spread
Publication/Aired: Pharmacy And Therapeutics – February 2008
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Aug 25, 2009
Ambien CR
Click on image to view the banner on AdPharm
Tired of morning coming in the middle of the night?
Silence your rooster with Ambien CR, so you can wake up less frequently and fall back asleep faster.
Get your 7-night free trial offer [inactive link]
Brand name: Ambien CR
Generic name/category: Zolpidem, Anxiolytics, Hypnotics, Imidazopyridines, Sedatives
Company: Sanofi-Aventis
Country/Market: USA, North America
Indication(s)/use: short-term treatment of insomnia
Target: Consumers (DTC)
Publication: 2009
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SleepMD
Behind every good morning is a good night’s sleep
America’s #1 selling drug-free sleep aid
Fall asleep faster. Wake up refreshed. Drug-free & non-habit forming. No daytime grogginess or fatigue.
Melatonin , also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring hormone found in most animals, including humans, and some other living organisms, including algae. Circulating levels vary in a daily cycle, and melatonin is important in the regulation of the circadian rhythms of several biological functions. Many biological effects of melatonin are produced through activation of melatonin receptors, while others are due to its role as a pervasive and powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA.
Melatonin has been studied for the treatment of cancer, immune disorders, cardiovascular diseases, depression, seasonal affective disorder (SAD), circadian rhythm sleep disorders and sexual dysfunction. Studies by Alfred J. Lewy at Oregon Health & Science University and other researchers have found that it may ameliorate circadian misalignment and SAD. Basic research indicates that melatonin may play a significant role in modulating the effects of drugs of abuse such as cocaine.
Treatment of circadian rhythm disorders
Exogenous melatonin taken in the evening is, together with light therapy upon awakening, the standard treatment for delayed sleep phase syndrome and non-24-hour sleep-wake syndrome. It appears to have some use against other circadian rhythm sleep disorders as well, such as jet lag and the problems of people who work rotating or night shifts.
Taken 30 to 90 minutes before bedtime, melatonin is put into the blood earlier than the brain’s own production and acts as a mild hypnotic.
A very small dose taken several hours before bedtime in accordance with the phase response curve for melatonin in humans (PRC) doesn’t cause sleepiness but, acting as a chronobiotic, does advance the phase slightly and is additive to the effect of using light therapy upon awakening. Light therapy may advance the phase about one to two-and-a-half hours and a small oral dose melatonin, timed correctly some hours before bedtime, can add about 30 minutes to the advance achieved with light therapy.
Brand name: SleepMD
Generic name/category: melatonin, sleep aid
Company: MD Products
Country/Market: USA, North America
Indication(s)/use: relief from occasional sleeplessness, insomnia
Target: Consumers (DTC)
Tagline: America’s #1 selling drug-free sleep aid
Publication: Men’s Journal April 2009
